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EC number: 274-354-1 | CAS number: 70161-18-1
The acute median lethal oral dose (LD50) to rats of Acid Orange 94 Refined was determined according to the
OECD Guideline for Testing of Chemicals No.420 ‘Acute Oral Toxicity – Fixed and EEC Methods for the determination of toxicity and other health effects. Commission Regulation No. 440/2008, Part B, Method B.1 bis. Acute Oral Toxicity: Fixed Dose Procedure. 30 May 2008. Dose Method’ Adopted 17 December 2001, according to GLP.
‘The melting point was determined using differential scanning calorimetry according to the OECD 102 guideline in accordance with GLP. The test item was determined to decompose from approximately 176 °C (449 K). As the test item decomposed, no value for melting point could be determined.’
The fixed dose method is a stepwise procedure that uses sighting investigations of one animal of a single sex per step followed by a main study of a further four animals. Depending on the mortality and/or the moribund status of the animals, on average two sighting steps and one or two main study steps may be necessary to allow a judgment on the acute toxicity of the test item.
The acute median lethal oral dose (LD50) to rats of Acid Orange 94 Refined was demonstrated to be greater than 2000 mg/kg body weight.
According to the Globally Harmonised System (GHS), described in Annex 2, Acid Orange 94 Refined does not meet the criteria for classification.
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