Registration Dossier
Registration Dossier
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EC number: 947-527-0 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Due to lack of comparative quantitative data, absorption rates of 100% are indicated for all three routes. There are no concern for bioaccumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
C14 Alkyl polyethoxy glycidylether are formed after the reaction of C14 alcohol ethoxylate (2EO) with epichlorohydrin.
There are no specific studies available that study absorption, distribution, metabolism or excretion of C14 Alkyl ethoxylated glycidylether. Due to lack of comparative quantitative data, absorption rates of 100% are indicated for all three routes. Profiling (see attached document with comparison to C12 Alkyl polyethoxy glycidylether) however indicates that oral absorption is likely to be high. As conservative approach, absorption via dermal route is also set at 100%, and an additional extrapolation factor of 2 from oral to inhalation route of exposure is taken into account for DNEL derivation.
The substance is not expected to be bio accumulative. No bio-accumulation study in fish or any other higher organism has been performed, but substance is readily biodegradable and has an estimated Kow of 3.5 based on solubility ratio of the substance separately in octanol and water (CMC value). After uptake, epoxides are hydrolized by epoxide hydrolases leading to diolsthat are readily further metabolized (glucuronidated and excreted). In repeated dose studies there is indication of liver induction suggested by increased liver weight at higher dose levels, indicative for a first pass metabolism after uptake. Thus, no bio-accumulation is expected. In addition, a BCF calculations (EpiSuite - BCFBAF Program v3.01) indicate a value of 116 L/kg wet-wt for C14 -Alkyl ethoxylated glycidylether, indicating a low bio-accumulation potential.
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