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EC number: 815-706-1 | CAS number: 20767-00-4
Three tissues of the human skin model EpiDermTMwere treated with the test item for 60 minutes.
The test item was applied directly to each tissue and spread to match the tissue size (0.63 cm2; as indicated by the supplier).
DPBS-buffer was used as negative control and 5% SDS solution was used as positive control.
After treatment with the negative control, the mean absorbance value was within the required acceptability criterion of 0.8 ≤ mean OD ≤ 2.8, OD was 1.5.
The positive control showed clear irritating effects. The mean value of relative tissue viability was reduced to 3.1% (required: ≤ 20%).
The variation within the tissue replicates of negative control, positive control and test item was acceptable (required: ≤ 18%).
After the treatment with the test item, the mean value of relative tissue viability was reduced to 86.9 %. This value is above the threshold for skin irritation potential (50%). Test items that induce values above the threshold of 50% are considered non-irritant to skin.
Therefore, the test itemL-Tyrosine, N-acetyl-3,5-dinitro-is considered
non-irritant to skin in the Reconstructed human Epidermis (RhE) Test Method.
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