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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Key result
Water solubility:
1 854 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
10 g/L
Incubation duration:
>= 48 - <= 72 h
Temp.:
20 °C
pH:
7
Remarks on result:
other: The measurement was conducted in demineralized water. Thus a pH value of 7 can be assumed.
Details on results:
Three flasks 1A - C with the same loading rate (10 g/L) were sampled during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h) and 2 – 6) were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature. Then, flasks 1A - 1C were taken from the shaker and tempered to (20.0 ± 0.5 °C). Samples were taken after homogenisation, membrane filtered and analysed with the HPLC. A rising tendency in the test item concentration of the solutions was found on day 3. Therefore, the flask C was sampled on the subsequent days (day 6 and 7) until no differences above 15 % and no rising tendency in the test item concentration of the solutions were observed.
Conclusions:
The mean test item concentration of the samples (flask 3- 6), which were used for the calculation of water solubility (at plateau) was 1854 mg/L ± 10 mg/L, corresponding to a relative standard deviation of 0.5 %.

Description of key information

In a study according to OECD 105 a test item concentration of 1854 mg/L ± 10 mg/L (mean ± standard deviation) was calculated, giving a relative standard deviation of 0.5 %.

Key value for chemical safety assessment

Water solubility:
1 854 mg/L
at the temperature of:
20 °C

Additional information