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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

First-aid measures

Eye contact

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if

present and easy to do. Continue rinsing. If eye irritation persists, get medical

advice/attention.

Skin contact

If ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs, seek

medical advice/attention. Wash contaminated clothing before re-use.

Inhalation

Move to fresh air. Oxygen or artificial respiration if needed. Obtain medical attention.

Ingestion

Obtain medical attention. Do NOT induce vomiting. Never give anything by mouth to an

unconscious person.

Notes to Physician

Material not fully tested.

Medical Surveillance

Employees who are pregnant, are breast-feeding, or who are concerned with other

reproductive issues should be encouraged to consult with the occupational health physician

monitoring worker's health.

Fire-fighting measures

Flammable Properties

Nonflammable

Extinguishing Media

Suitable extinguishing media: Dry chemical, Water spray, Foam

Unsuitable extinguishing media: Do NOT use water jet.

Protection of Firefighters

Specific hazards: Not available

Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained breathing apparatus.

Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx), hydrogen

halides

Further Information: HCl gas can form flammable or explosive mixtures with alcohols or

metals. In the event of fire and/or explosion do not breathe fumes.

Other information Decontaminate protective clothing and equipment before reuse.

Accidental release measures

Personal precautions

Use personal protective equipment.

Examples include tightly fitting safety goggles, lab coat and impervious gloves. Wear

respiratory protection. Depending on the nature of the spill (quantity and extent of spill)

additional protective clothing and equipment such as a self-contained breathing apparatus

may be needed.

Environmental precautions

Prevent release to drains and waterways. Prevent release to the environment.

Containment Methods

Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable

material.

Cleanup Methods

Contain and collect spillage and place in container for disposal according to local

regulations. Use a HEPA vacuum or moisten materials to minimize dust

generation during pick-up. Clean area with detergent and water after spill pick-up, if

appropriate. Handle waste materials, including gloves, protective clothing, contaminated

spill cleanup material, etc., as appropriate for chemically and pharmacologically similar

materials.

Handling and storage

Handling Precautions

Avoid exposure - obtain special instructions before use. Avoid formation of dust and

aerosols. Keep away from heat and sources of ignition. Prevent release to drains and

waterways.

ContainerRequirements

Store in sturdy containers appropriate to maintain the integrity of this material for its

intended use.

Storage Conditions

Store at room temperature. Protect against light. Keep away from heat, sparks and flames.

Transport information

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

Exposure limit(s) BMS-801598-01

Company Guideline 10 - < 100 µg/m3 (ECB 3 - For BMS Internal Use Only)

ACGIH --

Germany OEL --

UK MEL --

Recommended Industrial Hygiene Monitoring Methods

A specific exposure sampling method is not available. General - The health hazard risk of

handling this material is dependent on many factors, including physical form, % API in

material being handled, duration and frequency of process task, and effectiveness of controls.

If it is necessary to handle this compound outside of engineering controls, an exposure risk

assessment should be conducted and procedures documented by a qualified EHS professional.

Engineering Controls and Ventilation

Use process enclosures, containment technology, or other engineering controls to keep

airborne levels below recommended exposure limit. When handling quantities up to 15

milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air

changes per hour) is appropriate. When handling quantities from 15 milligrams to 1 kilogram,

work in a standard laboratory using a fume hood, biological safety cabinet(Class II, all types),

or approved vented enclosure. Quantities exceeding 1 kilogram should be handled in a

designated laboratory. A laminar flow/powder containment booth is recommended for

handling >1 kilograms of active substance. For manufacturing and pilot plant operations, use

direct coupling and closed transfer systems for all bulk transfers. Use dust tight valves as

appropriate. HEPA filtration of local exhaust ventilation (LEV) is required.

Respiratory protection

Use and selection of respiratory protection is based upon engineering controls in use and

potential for aerosol generation. When engineering controls are not sufficient control

exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate

(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure

control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying

respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control

guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters

(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure

control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied

air respirator (EN 139) operated in a pressure demand or other positive pressure mode when

exposures are 100-1000 times the exposure control guideline.

Eye protection

Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety

goggles (EN 166) may be required if splash potential exists or if corrosive materials are

present. Note: Choice of eye protection may be influenced by the type of respirator which is

selected.

Hand protection

Impervious nitrile, rubber and latex gloves are recommended (EN 420, EN 374). If material

is handled in solution, the solvent should also be considered when selecting protective clothing

material. Please note that employees who are allergic to natural rubber latex should use nitrile

gloves.

Skin and body protection

Wear a laboratory coat (EN 340) when handling quantities up to 1 kilogram. For quantities

over 1 kilogram, wear laboratory coat(EN 340)or coverall of low permeability (EN 1149-1).

For manufacturing operations, wear coverall of low permeability (EN 465/1149-1). For

manufacturing operations, wear coverall of low permeability (EN 1149-1).

Hygiene

Wash hands and face before breaks and immediately after handling the product.

Environmental exposure controls

Prevent release to drains and waterways.

Stability and reactivity

Stability

Chemical Stability

Stable under normal conditions.

Conditions to avoid

Not available

Materials to avoid

Not available

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions.: carbon oxides (COx),

nitrogen oxides (NOx), hydrogen halides

Hazardous reactions

Low to moderate potential for heat release when exposed to water, tBuOK/THF 20w%, 2 N

HCl (aq), MeOH/EtOH/IPA, glycol, CIP-100 (basic), CIP-200(acidic), and 1N NaOH (aq).

Sensitivity to static discharge/Dust exp.

Summary Statements

Although material has not been specifically tested, fine dust suspended in air in sufficient

concentration and in the presence of an ignition source may pose a potential explosion hazard.

Provide appropriate bonding and grounding protection to control static charge. Powder

handling equipment such as dust collectors, dryers, and mills may require additional protective

measures (e.g. explosion venting, inerting, etc.).

Disposal considerations

Advice On Disposal And Packaging

Disposal should be in accordance with applicable regional, national and local

laws and regulations. Local regulations may be more stringent than regional

or national requirements. This information presented only applies to the

material as supplied.

Other information

Disposal by incineration is recommended.