Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Beitrag zur Toxizität ω-H-polyfuorierter Carbonsäuren und einiger Alkohole gleicher C-Zahl
Author:
Schmidt P
Year:
1980
Bibliographic source:
Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 26, 9-13, 1980

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
ω-H-Dodekafluorheptanol-1, MW 332.1

Test animals

Details on test animals and environmental conditions:
female rats and rabbits

Test system

Details on study design:
test on the skin (pre-test) - not further specified procedure

Results and discussion

Any other information on results incl. tables

ω-H-polyfluoro caboxylic acids and their alcohols with a chain length of n = 2 -5 were tested for skin and eye irritation. Whereas the acids showed skin and eye irritating effects, the corresponding alcohols were not further tested for irritative properties since they were shown to be non irritants in pilot experiments. The (n = 5) acid has only mild irritating effects and is very well absorbed percutaneously. Alcohols with equal carbon atom numbers exhibit a weaker acute oral toxicity and have no irritative effects.

Applicant's summary and conclusion

Executive summary:

ω-H-polyfluoro caboxylic acids and their alcohols with a chain length of n = 2 -5 were tested for skin and eye irritation. Whereas the acids showed skin and eye irritating effects, the corresponding alcohols were not further tested for irritative properties since they were shown to be non irritants in pilot experiments.