Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Beitrag zur Toxizität ω-H-polyfuorierter Carbonsäuren und einiger Alkohole gleicher C-Zahl
Author:
Schmidt P
Year:
1980
Bibliographic source:
Zeitschrift für die gesamte Hygiene und ihre Grenzgebiete 26, 9-13, 1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
LD50 for intraperitoneal application
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
on-site breeder (Zam:Wistar-C)
pelleted standard feed Sorte R (VEB, Versuchstierproduktion) and water ad libitum
weight at study initiation: 150-180 g
Temperature: 20 ± 2 °C
Humidity: 57-59 %
Acclimation period: > 1 week

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 1,2-propane diol
Details on exposure:
VEHICLE
- Concentration in vehicle: 50 mg/mL
Doses:
no data
No. of animals per sex per dose:
no data
Details on study design:
Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of perished and surviving animals performed: yes
Statistics:
Statistics
LD50 was calculated with a computing system on the basis of Finneys probit analysis (1971).

Results and discussion

Any other information on results incl. tables

LD50 intraperitoneal: 225 mg/kg bw (175 -293 mg/kg bw)

Applicant's summary and conclusion