1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone

Endpoint summary

Description of key information

The predicted oral LD50 of the substance is 1981,52 mg/kg by Consensus method.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Documentation about the justification is provided in attachment (See Supporting information). The reliability assessment of the prediction is presented in the attached document as well (QPRF).

Qualifier:

equivalent or similar to guideline

Guideline:

other: ECHA guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals.

Specific details on test material used for the study:

CC(=O)N1C2=CC=CC=C2CCC3=CC=CC=C31

Species:

rat

Dose descriptor:

LD50

Effect level:

1 981.52 mg/kg bw

Remarks on result:

other: Consensus Method

The prediction was deemed to be reliable on the basis of the parameters listed above. The molecule falls into the applicability domain of the model.

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute oral LD50 of the substance was predicted to be 1981.52 mg/kg bw

Justification for classification or non-classification

Since the predicted LD50 is very close to the cut-off for classification/non-classification and considering the variability of the QSAR prediction, data are deemed to inconclusive for C&L.