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EC number: 916-839-9
CAS number: -
Scores when eyes were rinsed
Days after application
Rabbit 1, female
Rabbit 2, female
Rabbit 3, female
Scores when eyes were not rinsed
Rabbit 4, male
Rabbit 5, male
Rabbit 6, male
A study was performed to determine the eye
irritation potential of test item in rabbits. The procedure adopted was
the technique described in the "Appraisal of the Safety of Chemicals in
Foods, Drugs and Cosmetics (1959) of the US Association of Food and Drug
The substance was tested on 3 male and 3
female rabbits. Amounts of 0.1 g of the test substance were introduced
into the conjunctival sac of the left eye with a spatula. The treated
eyes of three rabbits were each rinsed with 10 ml lukewarm water about
30 seconds after treatment.
The total maximum is 80 for the cornea, 10
for the iris and 20 for the conjunctivae. The irritation index was found
to be 5.8 for the cornea, 0 the iris and 5 for the conjunctivae.
Discussion and conclusion
Although the criteria to calculate the
irritating potential are different, the scoring system used to record
the severity of the eye reactions followed in the current test are the
same as those reported into the OECD guideline.