N-(dodecylphenyl)naphthalen-1-amine

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Between 29 July 1999 and 15 December 1999.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Version / remarks:

HPLC Method, Method 117 of the OECD Guidelines for Testing of Chemicals, 30 March 1989.

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

No further details specified in the study report.

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

4.11

pH:

7.35

Remarks on result:

other: Temp not specified in the study report

Details on results:

Substances having a log10 Pow greater than 3 are regarded as having the potential to bioaccumulate in the environment.
APAN is estimated to have a pKa of approximately 1.6. The pH of the mobile phase (7.35) was such that the test material was tested in its unionised form.

Definitive Test

Calibration

The retention time of thiourea and the reference standards

Dead time	Retention time (mins)		Mean retention time (mins)
	Injection 1	Injection 2
Thiourea	2.622	2.417	2.520

 

Standard	Retention time (mins)		Mean retention time (mins)
	Injection 1	Injection 2
Benzene	6.467	6.571	6.519
Toluene	8.354	8.483	8.419
Naphthalene	9.980	10.131	10.056
Phenanthrene	16.497	16.721	16.609
Triphenylamine	34.657	35.138	34.898
DDT	48.156	48.719	48.438

 

The capacity factors (k) and log10 Pow value for the reference standards

Standard	Capacity factor (k)	Log10 k	Log 10 Pow
Benzene	1.587	0.201	2.1
Toluene	2.341	0.369	2.7
Naphthalene	2.991	0.476	3.6
Phenanthrene	5.592	0.748	4.5
Triphenylamine	12.851	1.109	5.7
DDT	18.225	1.261	6.2

 

Partition coefficient of sample

The retention times, capacity factors and log10 Pow values determined for the sample

Injection	Retention time (mins)	Capacity factor (k)	Log10 k	Log10 Pow
1	14.826	4.885	0.689	4.11
2	14.768	4.861	0.687	4.11

Mean log10 Pow: 4.11

Partition coefficient: 1.29 x 10⁴

Conclusions:

The partition coefficient of APAN has been determined to be 1.29 x 104, log10 Pow 4.11.

Executive summary:

Partition coefficient determined as 1.29 x 10⁴, log10 Pow 4.11, using the HPLC method, Method 117 of the OECD Guidelines for Testing of Chemicals, 30 March 1989.

Description of key information

Partition coefficient determined as 1.29 x 10⁴, log10 Pow 4.11.

Key value for chemical safety assessment

Log Kow (Log Pow):

4.11

Additional information

Partition coefficient determined as 1.29 x 10⁴, log10 Pow 4.11, using the HPLC method, Method 117 of the OECD Guidelines for Testing of Chemicals, 30 March 1989.