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EC number: 947-579-4
CAS number: 1449104-34-0
Table 1. Individual scores and mean scores for 24,
48 and 72 hours
Time After Treatment
Degree of Opacity
Mean (24 – 72 h)
The study was performed to OECD TG 405 and EU
Method B.5 under GLP to assess the irritancy potential of the test item
to the eye following a single application in the New Zealand White
rabbit. A volume of 0.1 ml of the test item was placed into the
conjunctival sac of one eye of two animals. The other eye remained
untreated and was used for control purposes. Assessment of ocular
damage/irritation was made approximately 1 hour and 24, 48 and 72 hours
following treatment. A single application of the test item to the
non-irrigated eye of two rabbits produced no corneal and iridial
effects. Moderate conjunctival irritation was noted in treated eyes 1
hour after treatment with minimal conjunctival irritation noted at the
24 and 48 Hour observations. All treated eyes appeared normal at the 72
hours. Under the conditions of this study, the test item is not
considered to be irritating to the eye.
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