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EC number: 605-404-6 | CAS number: 16535-55-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- (2,4-dioxo-1,3-benzoxazin-7-yl) ethyl carbonate
- EC Number:
- 605-404-6
- Cas Number:
- 16535-55-0
- Molecular formula:
- C11 H9 N O6
- IUPAC Name:
- (2,4-dioxo-1,3-benzoxazin-7-yl) ethyl carbonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 0.1 N NaOH
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- One group of Wistar rats, consisting of two males and two females, received a single oral dose of V194024 in 0.1 N NaOH at a dose level of 2000 mg/kg body weight (dose volume 10 ml/kg bw). Animals were subjected to daily observations and weekly determination of body weight. Macroscopic examination was performed at the end of the experimental period (day 8).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred
- Clinical signs:
- The only clinical sign noted was the hunched posture of one of the females during the first day. By the second day, this clinical sign was no longer observed.
- Body weight:
- Body weight gain of the animals during the 8 day study period was considered to be normal
- Gross pathology:
- No macroscopical findings were observed for the females.
The forestomach of the males had an irregular surface. One of the males also had nodules in the liver (right median lobe).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality was observed in the OECD 401 test with Wistar rats for 2000 mg/kg bw. The LD50 was therefore higher than 2000 mg/kg bw.
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