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Hazard for aquatic organisms

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Conclusion on classification

Three study reports (rated as Klimisch 1) on aquatic organisms are available covering three trophic levels: a primary producer (freshwater algae, represented by the model species Pseudokirchneriella subcapitata), a primary consumer (aquatic invertebrates, represented by the model species Daphnia magna), and a secondary consumer (aquatic vertebrate, represented by Gobiucyprus rarus). All tests were conducted following OECD test protocols fulfilling OECD-GLP requirements.

The most sensitive effect value was derived in the Fish, Acute Toxicity test (Baolian T. 2018) with a 96-h LC50 of 0.05 mg/L (geometric mean of measured concentrations). Based on this value according to CLP regulation (EC) 1272/2008, Annex I, Table 4.1.0. (a) and (b) (iii) the test item is classified as hazardous to the aquatic environment in the following categories:

- Aquatic Acute 1 (H400)

- Aquatic Chronic 1 (H410)


The multiplying factors (M-factors) are assigned according to CLP regulation (EC) 1272/2008, Annex I, Table 4.1.3 as following:

M-factor acute = 10, based on the 96-h LC50 (G. rarus) of 0.05 mg/L.

M-factor chronic = 10, equaling M-factor acute.

As chronic data is not available and Table 4.1.0 (a) (b, point iii) from the CLP regulation “is used for defining long-term aquatic hazard, the resulting M-factor derived for acute aquatic hazard classification is also applied to the long-term aquatic hazard classification.” Guidance on the Application of the CLP Criteria; Version 5.0 – July 2017, p. 509.

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