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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 2019-01-11 to 2019-01-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study performed to ISO 13320 with no significant deviations and run in OECD GLP certified lab.
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: CIPAC MT 187 “Particle Size Analysis by Laser Diffraction”, Handbook K, 2007
Version / remarks:
2007
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Specific details on test material used for the study:
Purity: 99.7%
Batch No.: 80031745a
Mass median aerodynamic diameter:
32.6 µm
Geometric standard deviation:
2.336
Key result
Percentile:
D10
Mean:
8.71 µm
St. dev.:
0.036
Key result
Percentile:
D50
Mean:
27.5 µm
St. dev.:
0.176
Key result
Percentile:
D90
Mean:
73.2 µm
St. dev.:
0.833
No.:
#1
Size:
< 10 µm
Distribution:
12.44 %

Particle Size Analysis using dry powder module

Average (µm)

Volume weighted mean

35.1

Mode

28.3

d10 (10 % of material is <)

8.71

d50 (50 % of material is <) (median)

27.5

d90 (90 % of material is <)

73.2

MMAD (mass median aerodynamic diameter)

32.6

Volume of sample < 10.00 µm

12.44 %

Conclusions:
MMAD of the test item was 32.6 µm, and D10, D50 and D90 were 8.71, 27.5 and 73.2 µm, respectively.
Executive summary:

The particle size was determined using the dry powder module according to ISO 13320 (Particle size analysis - Laser diffraction methods).

MMAD of the test item was 32.6 µm, and D10, D50 and D90 were 8.71, 27.5 and 73.2 µm, respectively.

Description of key information

MMAD of the test item was 32.6 µm, and D10, D50 and D90 were 8.71, 27.5 and 73.2 µm, respectively.

Additional information

The particle size was determined using the dry powder module according to ISO 13320 (Particle size analysis - Laser diffraction methods).

MMAD of the test item was 32.6 µm, and D10, D50 and D90 were 8.71, 27.5 and 73.2 µm, respectively.