Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report Date:
2019

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
GLP compliance:
yes (incl. certificate)
Type of study:
other: LuSens cell line

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

In vitro / in chemico

Results
Parameter:
other: The viability values
Run / experiment:
LuSens test
Value:
>= 88

Any other information on results incl. tables

Under the experimental conditions of this study, the test item, 1,2,4,5-Tetramethylimidazole, was positive in the LuSens assay and is therefore considered to have the potential to activate the Nrf2 transcription factor.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
positive