hydrogenated decyl olive oil esters

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: REACH guidance on QSARs R.6 (QSPR model adapted specifically from OECD test guideline 201)

Principles of method if other than guideline:

The growth inhibition of algae was determined using a validated calculation method for the Mechanism of Action (MechoA) in question (MechoA 2.1, i.e. esters whose hydrolysis products are narcotics) (3). This method has
previously been validated in an internal publication for acute exposure of non-polar narcosis compounds (Bicherel and Thomas, 2014). The algorithm is based on a QSAR model which has been validated to be compliant with the OECD recommandations for QSAR modeling (OECD, 2004; OECD, 2007) (5,6). The QSAR model is based on validated data from a training set of 40 chemicals derived from 72-hour test on algae, for which the concentrations of the test item had been determined by chemical analyses over the test period. Further to this the effective loading rate of the WAF is determined by using a series of calculation steps using phase equilibrium thermodynamics and excluding the non-bioavailable fraction, this approach is based on validated data derived from 72-hour ErL50 tests on algae, for which the concentrations of the test item had been determined by chemical analyses over the test period.

Test material

Test material information

Constituent 1

Reference substance name:

hydrogenated decyl olive oil esters

Molecular formula:

not applicable

IUPAC Name:

hydrogenated decyl olive oil esters

Specific details on test material used for the study:

SMILES:
Decyl octadecanoate: CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCC
Decyl hexadecanoate: CCCCCCCCCCCCCCCC(=O)OCCCCCCCCCC

Results and discussion

Effect concentrations

Key result

Duration:

72 h

Dose descriptor:

EL50

Basis for effect:

growth rate

Remarks on result:

other: > water solubility limit

Remarks:

Calculated value

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Conclusions:

The 72 -hour EL50 for algal growth inhibition was estimated as higher than water solubility limit of the test item.