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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
La lithase oxalique expérimentale à l'acide glyoxylique chez le rat. Essai de prévention par la succinémide.
Author:
Melon JM, Thomas J, Pierre R
Year:
1971
Bibliographic source:
Thérapie 26, 991-998
Reference Type:
publication
Title:
Succinimide
Author:
Not given
Year:
1974
Bibliographic source:
Drugs of today/Medicamentos de actualidad 10, 224-226

Materials and methods

Principles of method if other than guideline:
Acute toxicity test
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Succinimide
EC Number:
204-635-6
EC Name:
Succinimide
Cas Number:
123-56-8
Molecular formula:
C4H5NO2
IUPAC Name:
pyrrolidine-2,5-dione

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
weight: approx 225g

Administration / exposure

Route of administration:
oral: gavage
Doses:
1 g/kg
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Preliminary study:
In a preliminary study the LD50 has been evaluated to be 14 g/kg (not further specified).
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
14 000 mg/kg bw
Mortality:
No mortality was observed at 1 g/kg. In a preliminary study the LD50 has been evaluated to be 14 g/kg (not further specified).

Applicant's summary and conclusion

Conclusions:
The LD50 for rats is reported to be 14000 mg/kg.