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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Justification for type of information:
The estimation for short-term toxicity to green algae of the test material was performed with US-EPA software ECOSAR v1.11. ECOSAR is currently programmed to identify over 120 chemical classes. For those classes, there are a more than 600 QSARs based on publicly available experimental data and confidential studies collected under the EPA New Chemicals Program. For each class, a standard EPA New Chemicals Program aquatic toxicity profile will be created using available QSARs and/or alternate QSAR approaches and professional judgment.

Data source

Reference
Reference Type:
other: QSAR
Title:
ECOSAR, ecological structure-activity relationships.
Author:
U.S. Environmental Protection Agency
Year:
2012
Bibliographic source:
ECOSAR v1.11, United States Environmental Protection Agency

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: REACH guidance on QSARs Chapter R.6 , May 2008
Version / remarks:
Software package: ECOSAR v1.11, U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, 1200 Pennsylvania Ave., N.W. Washington, DC 20460-0001, USA.
Principles of method if other than guideline:
The estimation for short-term toxicity to green algae of the test material was performed with US-EPA software ECOSAR v1.11. ECOSAR is currently programmed to identify over 120 chemical classes. For those classes, there are a more than 600 QSARs based on publicly available experimental data and confidential studies collected under the EPA New Chemicals Program. For each class, a standard EPA New Chemicals Program aquatic toxicity profile will be created using available QSARs and/or alternate QSAR approaches and professional judgment.
GLP compliance:
no
Remarks:
not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Succinimide
EC Number:
204-635-6
EC Name:
Succinimide
Cas Number:
123-56-8
Molecular formula:
C4H5NO2
IUPAC Name:
pyrrolidine-2,5-dione
Specific details on test material used for the study:
- Name of test material (as cited in study report) : 2,5-Pyrrolidinedione
- SMILES : O=C(NC(=O)C1)C1

Sampling and analysis

Details on sampling:
Not applicable

Test solutions

Details on test solutions:
Not applicable

Test organisms

Test organisms (species):
other: Green algae, not further specified
Details on test organisms:
No details available.

Study design

Test type:
other: Estimation from QSAR
Water media type:
not specified
Total exposure duration:
96 h

Test conditions

Hardness:
Not applicable
Test temperature:
Not applicable
pH:
Not applicable
Dissolved oxygen:
Not applicable
Salinity:
Not applicable
Conductivity:
Not applicable
Nominal and measured concentrations:
Not applicable

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
3 238 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
biomass
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
605 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
biomass

Any other information on results incl. tables

The prediction for short-term toxicity to green algae of the test substance was determined by the computer program ECOSAR v1.11 by US-EPA .ECOSAR is currently programmed to identify over 120 chemical classes. For those classes, there are a more than 600 QSARs based on publicly available experimental data and confidential studies collected under the EPA New Chemicals Program. For each class, a standard EPA New Chemicals Program aquatic toxicity profile will be created using available QSARs and/or alternate QSAR approaches and professional judgment.

Adequacy of the QSAR:

- QSAR model is scientifically valid.

- The substance falls within the applicability domain of the QSAR model.

- The prediction is fit for regulatory purpose.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Remarks:
Scientifically accepted calculation method.
Conclusions:
The predicted value for green algae EC50(96h) of 3228 mg/L use the Neutral Organics QSAR equations which represent baseline toxicity potential (minimum toxicity) assuming a simple non-polar narcosis model.
Executive summary:

The study report describes a scientifically accepted calculation method for the prediction of short-term toxicity to green algae using the US-EPA software ECOSAR v1.11. No GLP criteria are applicable for the usage of this tool and the QSAR estimation is easily repeatable. The substance falls within the applicability domain of the QSAR model, hence, the result can be considered as reliable. The result is adequate for the regulatory purpose.