Registration Dossier
Registration Dossier
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EC number: 202-903-7 | CAS number: 100-94-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Inhalation hazard test, saturated atmosphere was tested, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- Method: BASF test
- GLP compliance:
- no
- Remarks:
- GLP was not compulsatory at this time
- Test type:
- other: Inhalation hazard test
Test material
- Reference substance name:
- Dibenzyldimethylammonium chloride
- EC Number:
- 202-903-7
- EC Name:
- Dibenzyldimethylammonium chloride
- Cas Number:
- 100-94-7
- Molecular formula:
- C16H20N.Cl
- IUPAC Name:
- dibenzyldimethylammonium chloride
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Gassner
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on inhalation exposure:
- To generate saturated atmosphere, air was directed though a 5 cm layer of the test material at 20°C and 100°C respectively.
- Duration of exposure:
- 8 h
- No. of animals per sex per dose:
- 20°C vapour: 12 animals
100°C vapour: 12 animals - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- other: LT0
- Remarks:
- 20°C vapour
- Effect level:
- 13.75 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality observed
- Dose descriptor:
- other: LT0
- Remarks:
- 100°C vapour
- Effect level:
- 43.36 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality observed
- Mortality:
- No mortalities after 8-hour exposure to an atmosphere enriched with the test substance vapour generated at 20 and 100°C.
- Clinical signs:
- other: Irritation of mucous membranes was observed.
- Gross pathology:
- No adverse effects observed.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
