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EC number: 947-964-7 | CAS number: -
Table 1: OD values and viability percentages of the controls:
Optical Density (OD)
Negative Control:NaCl (9 g/L saline)
Positive Control:Glacial acetic acid
Table 2: OD values and viability percentages of the test item (including corrected values):
The study was conducted to determine the skin corrosion potential of the test item. Disks of EPISKIN (two units) were treated with the test item and incubated for 4 hours (±10 min) at room temperature. Exposure of the test material was terminated by rinsing with PBS 1x solution. The viability of each disk was assessed by incubating the tissues for 3 hours (±15 min) with 5±1 % CO2 in a ≥ 95% humidified atmosphere and protected from light. The formazan precipitated was then extracted using acidified isopropanol and quantified spectrophotometrically. NaCl (9 g/L saline) and glacial acetic acid treated epidermis were used as negative and positive controls, respectively. The test item did not show significantly reduced cell viability in comparison to the negative control after four hours of exposure. Both individual tissue viabilities were above 35 % of the mean negative control value. The average test item treated tissue viability was 103 %. Positive and negative controls showed the expected cell viability values within acceptable limits. The experiment was considered to be valid. The results obtained from this in vitro skin corrosion test, using the EPISKIN model, indicated that the test item reveals no skin corrosion potential. This result can be used together with further information on the irritative nature of the substance to decide on its final classification.
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