2-amino-4,6-dinitrophenol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

1992

Materials and methods

Principles of method if other than guideline:

The skin irritation potential of Picramic Acid (2.5% w/v aqueous solution, buffered to pH 7) was evaluated using three rabbits.

GLP compliance:

not specified

Test material

Test material information

1

Reference substance name:

2-amino-4,6-dinitrophenol

EC Number:

202-544-6

EC Name:

2-amino-4,6-dinitrophenol

Cas Number:

96-91-3

Molecular formula:

C6H5N3O5

IUPAC Name:

2-amino-4,6-dinitrophenol

Test animals

Species:

rabbit

Results and discussion

In vivo

Results

Irritation parameter:

other: Skin irritation

Basis:

animal: All animals

Time point:

48 h

Score:

0

Any other information on results incl. tables

Skin irritation: Reactions were not observed in any of the animals tested.

Applicant's summary and conclusion

Conclusions:

Skin irritation: reactions were not observed in any of the animals tested.

Executive summary:

The skin irritation potential of Picramic Acid (2.5% w/v aqueous solution, buffered to pH 7) was evaluated using three rabbits (strain not stated). The test solution (0.5 ml) was applied to an abraded and an intact site (both clipped free of hair) on the back of each animal. Each site was covered with a patch made of surgical gauze, and the trunk was wrapped with an impervious material. At the end of the 24 h contact period and 48 h later, reactions were scored.

Skin irritation: reactions were not observed in any of the animals tested.