Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Reliable predicted value obtained by the OECD QSAR Toolbox using trend analysis within category members.The prediction fulfilling the OECD criteria for the validation of QSAR models with respect to • a defined endpoint • unambiguous algorithm • a defined domain of applicability • appropriate measure of goodness-of-fit, robustness and predictivity

Data source

Reference
Reference Type:
other: OECD QSAR Toolbox Report
Title:
Unnamed
Year:
2018

Materials and methods

Principles of method if other than guideline:
Calculation using QSAR Toolbox based on trend analysis within category members.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(methoxymethyl)-3-methyl-aniline
EC Number:
821-826-5
Cas Number:
1472650-01-3
Molecular formula:
C9 H13 N O
IUPAC Name:
2-(methoxymethyl)-3-methyl-aniline
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
not required

Test organisms

Test organisms (species):
Daphnia magna

Study design

Total exposure duration:
48 h

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
2.27 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
behaviour

Applicant's summary and conclusion