Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-073-0 | CAS number: 50-97-5
Table 3. Results and Discussion
No. of animals
Dermal Responses(Timing post- exposure)
Three Minutes Exposure
One Hour Exposure
Absent to very slight
Four Hours Exposure
No abnormal physical signs were observed among all three animals.
Two animals gained weight and one study animal lost weight by study termination.
Primary Irritation Index (PII) =0.4Response Category:Practically Non-irritating (Negligible)
DOT:Not corrosive, NoEPA:NotGHS:Not packing group assignment Classified Classified
OECD 404 (2016) -the irritant or corrosive effects of the test article was assessed following application to the clipped skin of white New Zealand rabbit. The test article (0.5 g) was applied dermally to Site 1 for exposure period of 3 minutes under occlusive patch. Since the reaction of the initial animal did not produce a corrosive or severely irritating effect, two additional animals (one female and one male) were added to the study. All three animals were dosed at Site 2 for an exposure period of one hour and Site 3 for an exposure period of four hours. Erythema and edema were scored at 1, 24, 48 and 72 hours after patch removal for the one and four-hour exposures. Animals were observed for mortality, toxicological and pharmacological effects at least once daily. Body weights were recorded pre-test and at termination.
No abnormal physical or systemic signs were observed among all three animals. Two animals gained weight and one study animal lost weight by study termination. No mortality reported.
Very slight erythema and oedema was noted within 24 hours post exposure and it was fully reversible. The Primary Irritation Index (PII) of theist item was reported as 0.4.
Under the condition of the study, it was concluded that test item was not corrosive and does not cause irritation to the rabbits’ skin. Therefore, the test item does not meet the criteria for classification according to the Globally Harmonized Classification System and to the Regulation (EC) No. 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixture.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again