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EC number: 200-073-0 | CAS number: 50-97-5
Table 1. Clinical Observations and Mortality Data
(# dead / total)
Time range of deaths
Number with evident toxicity
(# / total)
Table 2. Dermal effects Noted After Initiation of Exposure
Days after exposure
Edema(# / total)
Other(# / total)
0 = No reactions
Bl= Blanching of the skin
Br= Light brown discoloration of the epidermis
A study was performed according to OECD TG 402; Acute Toxicity (Dermal) and in accordance with GLP to assess the acute dermal toxicity of the test substance in the Wistar (RccHan:WIST) strain rat. A group of ten animals (five males and five females) were given a single, 24 hour, semi‑occluded dermal application of the test item to intact skin at a dose level of 2000 mg/kg body weight for a duration of 24 hour under semi-occluded condition and sequent observation for 14 days.
There was no mortality during the study. There were no signs of system toxicity or abnormalities on necropsy. All animals showed expected gains in body weight during the study. Very slight erythema, blanching of the skin and light brown discoloration of the epidermis were noted during the observation period. Treated skin sites of female animals appeared normal two days after treatment and of male animals six days after treatment.
Under the conditions of this study the dermal LD50 was established to exceed 2000 mg/kg bw in Wistar (RccHan:WIST) strain rat. Applicant assessment indicates, under the conditions of this study, and according to the GHS criteria, the LD50 cut-off value was considered to be greater than 5000 mg/kg body weight.
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