Registration Dossier
Registration Dossier
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EC number: 443-860-6 | CAS number: 302776-68-7
Endpoint summary
Administrative data
Description of key information
A skin sensitization study was conducted (Guinea Pig Maximization Test) with Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate according to the OECD TG 406. The test substance showed no dermal sensitizing effect. No skin reactions were observed in any of the animals of the test group and control group after the challenge treatment with 25% of the test substance in olive oil.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
As key study, a guinea pig maximisation test according to OECD TG 406 and GLP was conducted with Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoate in olive oil using female Dunkin-Hartley guinea pigs (BASFAG30H0408/992238).
Skin irritation findings were observed in animals of the test groups and the control groups at the injection site following intradermal induction (5% test substance) and later at the same site in the animals of the same groups after the epicutaneous induction (25% test substance). The challenge exposure (24 hours with 25% test substance in olive oil) caused no skin reactions in any of the study animals (test group animals and control group) when evaluated 24 and 48 hours after removal of the patch.
Therefore the test substance Hexyl 2-(1-(diethylaminohydroxyphenyl)methanoyl)benzoatewas found to have no sensitizing potential.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
no data available
Justification for classification or non-classification
The present data on dermal sensitization do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC, and therefore, a non-classification is warranted.
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