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EC number: 807-717-5
CAS number: 295800-70-3
A primary skin irritation test was conducted with rabbits to determine
the potential for Spectrace® MD-810 Marker (Solvent
Free) to produce irritation after a single topical application.
Five-tenths of a gram of the test substance was moistened with distilled
water and applied to the skin of three healthy rabbits
for 4 hours. Following exposure, dermal irritation was evaluated by the
method of Draize et al.
All animals appeared active and healthy. There were no other signs of
gross toxicity, adverse pharmacologic effects or abnormal behavior.
There was no edema observed at any treated site during this study. One
hour after patch removal, all three treated sites
exhibited very slight erythema. All animals were free of dermal
irritation by 24 hours. The Primary Dermal Irritation Index (PDII)
calculated for this test substance was 0.3.
A primary eye irritation test was conducted with rabbits to determine
the potential for Spectrace® MD-8 10 Marker
(Solvent Free) to produce irritation from a single instillation via the
ocular route. Under the conditions of this study,
the observed ocular effects of Spectrace® MD-810 Marker (Solvent Free)
were slight irritation to the eye.
Prior to its use in the study, the test substance was ground to a fine
powder. One-tenth of a milliliter (0.03 grams) of
the ground test substance was instilled into the right eye of three
healthy rabbits. The left eye remained untreated
and served as a control. Ocular irritation was evaluated by the method
of Draize et al.1. One hour after test substance instillation, all three
treated eyes exhibited corneal opacity, iritis, and conjunctivitis. The
overall incidence and severity of irritation decreased with time. All
animals were free of ocular irritation by 72hours.
Under the conditions of this skin irritation study, Spectrace MD-8 10
Marker (Solvent Free) caused only very slight irritation which was
resolved by 24 hrs. Therefore, this material would not be classified as
a skin irritant under EU GHS criteria.
One hour after test substance instillation, all three treated eyes
exhibited corneal opacity, intis, and conjunctivitis. The overall
incidence and severity of irritation decreased with time. All animals
were free of ocular irritation by 72 hours. The Maximum Mean Total Score
of Spectracem MD-8 10 Marker (Solvent Free) is 21.3. Slight eye
irritation was observed. However, the mean 24, 48, and 72 hour cornea,
iris, conjunctivae, and chemosis scores did not rise to the level of
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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