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EC number: 944-860-3 | CAS number: -
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 07/03/2018-08/03/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6 (following OCDE 202)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Constituent citric acid : OC(=O)CC(O)(CC(=O)O)C(=O)O
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Vehicle:
- not specified
- Details on test solutions:
- Not applicable
- Test organisms (species):
- Daphnia sp.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.22 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: QSAR predicted value
- Reported statistics and error estimates:
- 95% confidence limits (g test item.L-1) : 0.14 – 0.33
- Validity criteria fulfilled:
- not applicable
- Executive summary:
The toxicity to daphnids of citric acid is : 0.22 g/L
Based on a constituent approach, the acute toxicity to daphnids of EXTRACT OF ALLIUM CEPA (AMARYLLIDACEAE) BULB AND CITRUS LIMON (RUTACEAE) PULP AND SODIUM CHLORIDE is considered as greater than 100 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 07/03/2018-08/03/2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6 (following OCDE 202)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Constituent glucose Smile : C([C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)O)O)O
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Vehicle:
- not specified
- Details on test solutions:
- Not applicable
- Test organisms (species):
- Daphnia sp.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 26 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: QSAR predicted value
- Reported statistics and error estimates:
- 95% confidence limits (g test item.L-1) : 23 - 28
- Validity criteria fulfilled:
- not applicable
- Executive summary:
The toxicity to daphnids of glucose is : 26 g/L
Based on a constituent approach, the acute toxicity to daphnids of EXTRACT OF ALLIUM CEPA (AMARYLLIDACEAE) BULB AND CITRUS LIMON (RUTACEAE) PULP AND SODIUM CHLORIDE is considered as greater than 100 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 07/03/2018-08/03/2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6 (following OCDE 202)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Constituent sucrose Smile : C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)CO)O)O)CO)O)O)O)O
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
- Vehicle:
- not specified
- Details on test solutions:
- Not applicable
- Test organisms (species):
- Daphnia sp.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 180 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: QSAR predicted value
- Reported statistics and error estimates:
- 95% confidence limits (g test item.L-1) : 164 – 198
- Validity criteria fulfilled:
- not applicable
- Executive summary:
The toxicity to daphnids of sucrose is : 180 g/L
Based on a constituent approach, the acute toxicity to daphnids of EXTRACT OF ALLIUM CEPA (AMARYLLIDACEAE) BULB AND CITRUS LIMON (RUTACEAE) PULP AND SODIUM CHLORIDE is considered as greater than 100 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Principles of method if other than guideline:
- Results from : Khangarot BS, Ray PK; Ecotoxicol Environ Saf 18 (2): 109-120 (1989) Available from, as of November 21, 2006:http://cfpub.epa.gov/ecotox/quick_query.htm
- GLP compliance:
- no
- Specific details on test material used for the study:
- Constituent sodium chloride : [Na+].[Cl-]
- Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia sp.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 0.403 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Reported statistics and error estimates:
- 95% confidence limits (g test item.L-1) : 0.3407 – 0.4692
- Validity criteria fulfilled:
- not applicable
- Executive summary:
The toxicity to daphnids of sodium chloride is : 0.4026 g/L
Based on a constituent approach, the acute toxicity to daphnids of EXTRACT OF ALLIUM CEPA (AMARYLLIDACEAE) BULB AND CITRUS LIMON (RUTACEAE) PULP AND SODIUM CHLORIDE is considered as greater than 100 mg/L.
Referenceopen allclose all
The MODEL used predicted that citric acid has a EC50 value of 0.22 g item /L on daphnids.
The MODEL used predicted that glucose has a EC50 value of 26 g item /L on daphnids.
The MODEL used predicted that sucrose has a EC50 value of 180 g item /L on daphnids.
Description of key information
The immobility of the daphnids was determined using validated QSAR models for the Mechanisms of Action (MechoA) associated to the constituents, i.e. MechoA 1.1: baseline toxicity (non-polar narcosis) and MechoA 5.2: carboxylic acids. The QSAR models used are based on validated data derived from 48-hour test on daphnids, for which the concentrations of the test item had been determined by chemical analyses over the test period.
Based on a constituent approach, the acute toxicity to daphnids of EXTRACT OF ALLIUM CEPA (AMARYLLIDACEAE) BULB AND CITRUS LIMON (RUTACEAE) PULP AND SODIUM CHLORIDE is considered as greater than 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
