Registration Dossier
Registration Dossier
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EC number: 403-470-9 | CAS number: - CYANEX (R) EXTRACTANT; CYANEX 923 EXTRACTANT
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Type of information:
- experimental study
- Adequacy of study:
- key study
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The micronucleus was performed according to a protocol recommended for submission to the Canadian agencies. Performed under GLP.
- GLP compliance:
- yes
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- IUPAC Name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
- No. of animals per sex per dose:
- Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 1 hours
Male: 48 mg/kg; No. of animals: 5; Sacrifice time: 1 hours
Male: 159 mg/kg; No. of animals: 5; Sacrifice time: 1 hours
Male: 476 mg/kg; No. of animals: 5; Sacrifice time: 1 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 1 hours
Female: 48 mg/kg; No. of animals: 5; Sacrifice times: 1 hours
Female: 159 mg/kg; No. of animals: 5; Sacrifice times: 1 hours
Female: 476 mg/kg; No. of animals: 5; Sacrifice times: 1 hours
Results and discussion
Test results
- Sex:
- male/female
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity : 476 mg/kg/bw
- Additional information on results:
- Observations:
one male and female of 476 mg/kg bw were found dead;
surviving animals of this dose group showed lethargy, rough hair coat and bloated abdomen.
Applicant's summary and conclusion
- Conclusions:
- No effects were observed during this evaluation on the in vivo genotoxiicty (micronucleus) on mice of the test substance.
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