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Short-term toxicity to aquatic invertebrates

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Based on read-across from a structural analogue (Modified Small Vinyl Ester) is concluded that Small Vinyl Ester will induce less than 30% immobility in Daphnia at its water solubility limit, which is approximately 0.42 mg/L based on the solubility of main constituent bisGMA. 

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The read-across analogue Modified Small Vinyl Ester was tested for short-term toxicity in invertebrates according to REACH Annex VII section 9.1.1 (Daphnia sp. acute immobilisation test; EU Method C.2), applying the OECD Guideline 202. The study met the acceptability criteria prescribed by the protocol and was considered valid. Under the conditions of the test, Modified Small Vinyl Ester induced not more than 30% immobility in Daphnia magna at the water solubility limit of Modified Small Vinyl Ester, being approximately 7 mg/L weighted average for the two main constituents, bisGMA (0.42 mg/L) and monomaleic-bisGMA (37.6 mg/L). Hence, the 48h-EC50 for Modified Small Vinyl Ester was above the water solubility limit (7 mg/L). Small Vinyl Ester does not contain monomaleic-bisGMA. The water solubility limit for Small Vinyl Ester is approximately 0.42 mg/L based on bisGMA. It is evaluated that the result and conclusion for Modified Small Vinyl Ester is valid also for Small Vinyl Ester based on the chemical similarity. Using read-across from Modified Small Vinyl Ester to Small Vinyl Ester it is concluded that the acute toxicity of Small Vinyl Ester (48h-EC50) is higher than the water solubility for Small Vinyl Ester (0.42 mg/).

Based on the chemical similarity of Small Vinyl Ester and Modified Small Vinyl Ester, the fact that Modified Small Vinyl Ester, which is more water soluble than Small Vinyl Ester, has low toxicity, corroborates the fact that Small Vinyl Ester has no or little toxicity to Daphnia, as a higher water solubility would result in a higher concentration in water and thus in a higher exposure concentration.

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