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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

A study conducted according to OECD Guidelines for "Fish Acute Toxicity Test" (Procedure 203, July 17, 1992) and EEC directive 92/69/EEC is used for the evaluation. The no-observed-effect concentration (NOEC) was = 100 mg/l (nominal concentration). The LC100 could not be determined.
The LC50 was > 100 mg/l (nominal concentration), as estimated from the absence of mortality in the test group using binominal theory to calculate the level of confidence of 99%. However, no Small Vinyl Ester was found in the test vessel. Therefore, read-across of data from a structural analogue (Modified Small Vinyl Ester) is used. Modified Small Vinyl Ester did not induce toxicity in fish at a WAF loading rate of 100 mg/L. The water solubility limit for Modified Small Vinyl Ester was found to approximately 7 mg/L weighted average. The water solubility rate for Small Vinyl Ester is approximately 0.42 mg/L based on the solubility of main constituent bisGMA. Therefore, 96h-LC0 for Small Vinyl Ester is evaluated to higher than 0.42 mg/L.

Key value for chemical safety assessment

Additional information

The no-observed-effect concentration (NOEC) was = 100 mg/l (nominal concentration). The LC100 could not be determined.

The LC50was > 100 mg/l (nominal concentration), as estimated from the absence of mortality in the test group using binominal theory to calculate the level of confidence of 99%.

Modified Small Vinyl Ester was tested for short-term toxicity in carp in accordance with the guideline OECD 203. No toxicity was found at a loading rate of 100 mg/L (WAF). The 96h-LC0 is above the water solubility limit for Modified Small Vinyl Ester. In this study, the measured concentrations of Modified Small Vinyl Ester in the test vessels were at or above the water solubility limit for Modified Small Vinyl Ester, being approximately 7 mg/L weighted average based on solubility for the two main constituents, bisGMA (0.42 mg/L) and monomaleic-bisGMA (37.6 mg/L). Small Vinyl Ester does not contain any monomaleic-bisGMA. Thus, the water solubility limit for Small Vinyl Ester is approximately 0.42 mg/L based on bisGMA. The results of the short-term toxicity testing on Modified Small Vinyl Ester corroborate that Small Vinyl Ester is not toxic to fish at its water solubility limit (0.42 mg/L).

Thus, Small Vinyl Ester showed no acute toxicity in fish at a WAF loading rate 100 mg/L. However, no Small Vinyl Ester was found in the test vessel. This was confirmed in a similar test with Modified Small Vinyl Ester in which no toxicity at a WAF loading rate of 100 mg/L was observed. The water solubility limit for Modified Small Vinyl Ester was found to approximately 7 mg/L weighted average. The water solubility rate for Small Vinyl Ester is approximately 0.42 mg/L. Therefore, 96h-LC0 for Small Vinyl Ester is evaluated to be higher than 0.42 mg/L. Based on the chemical similarity of Small Vinyl Ester and Modified Small Vinyl Ester, the fact that Modified Small Vinyl Ester, which is more water soluble than Small Vinyl Ester, is not toxic, corroborates the findings that Small Vinyl Ester is not toxic, as a higher water solubility would result in a higher concentration in water and thus in a higher exposure concentration.