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Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal. Study conducted according a standardised method.
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
other: Methods for Examination of Waters and Associated Materials: 5 Day Biochemical Oxygen Demand (BOD5)
Version / remarks:
2nd edition 1988 (with Dissolved oxygen in waters, Amendment 1988)
Procedure recommended by the Standing Committee of Analysts of the UK Department of the Environment
Principles of method if other than guideline:
The effect of the test substance on the degree of biodegradation of two easily biodegradable substances, glucose and glutamic acid, was also considered to measure the inhibition potential of the substance.
GLP compliance:
not specified
Specific details on test material used for the study:
- Synonym: CYPHOS® IL 169 PHOSPHONIUM SALT
- Purity/Composition: >= 95%
Analytical monitoring:
not specified
Vehicle:
no
Test organisms (species):
other: Unknown
Test type:
not specified
Water media type:
freshwater
Limit test:
no
Total exposure duration:
5 d
Hardness:
Not specified
Test temperature:
Not specified
pH:
Not specified
Dissolved oxygen:
Not specified
Salinity:
Not specified
Conductivity:
Not specified
Nominal and measured concentrations:
1, 10 and 100 mg/L (nominal)
Reference substance (positive control):
no
Duration:
5 d
Dose descriptor:
NOEC
Effect conc.:
< 1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Inhibition of biodegradation of glucose/glutamate
Details on results:
After 5 days of exposition, the inhibition of glucose/glutamate biodegradation was 100% at concentrations of 10 and 100 mg/L, and of 78% at 1 mg/L.
Therefore, the test material was inhibitory to the microorganisms at all tested concentrations.
Validity criteria fulfilled:
not specified
Conclusions:
In this test the inhibitory effect of the test substance on the biodegradation of two easily biodegradable substances was studied.
The test material showed little inhibition.
Executive summary:

In this study, the inhibitory effect of the test substance Tributyl(ethyl) phosphonium diethylphosphate on the biodegradation of two easily biodegradable substances (glucose and glutamic acid) was tested according to a UK guideline (Methods for Examination of Waters and Associated Materials: 5 Day Biochemical Oxygen Demand (BOD5)).

The degree of inhibition of the degradation of the two reference substances was 19% at 100 mg/L; 15% at 10 mg/L and 16% at 1 mg/L. Therefore, it was concluded that the substance showed little inhibitory effect to the microorganisms.

Description of key information

In this study, the inhibitory effect of the test substance Tributyl(ethyl) phosphonium diethylphosphate on the biodegradation of two easily biodegradable substances (glucose and glutamic acid) was tested according to a UK guideline (Methods for Examination of Waters and Associated Materials: 5 Day Biochemical Oxygen Demand (BOD5)).

The degree of inhibition of the degradation of the two reference substances was 19% at 100 mg/L; 15% at 10 mg/L and 16% at 1 mg/L. Therefore, it was concluded that the substance showed little inhibitory effect to the microorganisms.

Key value for chemical safety assessment

Additional information