Registration Dossier
Registration Dossier
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EC number: 201-255-2 | CAS number: 80-17-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- BG Chemie - Potential Health Hazards of Existing Chemiclas (TOXIKOLOGISCHE BEWERTUNG zu Benzolsulfonsäurehydrazid, BG-Nr. 220)
- Author:
- Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)
- Reference Type:
- publication
- Title:
- A study of certain substituted sulphonohydrazides for carcinogenicity in mice
- Author:
- R. J. W. Cremlyn, F.J.C. Roe
- Year:
- 1 971
- Bibliographic source:
- R.J.W. Cremlyn, F.J.C. Roe, A study of certain substituted sulphonohydrazides for carcinogenicity in mice, Food Cosmet. Toxicol., 9, 2, 1971, 319-320,
Materials and methods
- GLP compliance:
- not specified
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 8 weeks ol at the start of the study
Administration / exposure
- Route of administration:
- other: gastric instillation
- Vehicle:
- other: aqueous gelatin
- Remarks:
- 2 mg BSH in 0.2 ml 3% aqueous gelatin
- Details on exposure:
- 5 doses/week for 4 wk, followed by 3 doses/week to a total of 158 doses (also for control group)
Results and discussion
Any other information on results incl. tables
After 60 weeks, the surviving animals were examined for tumours.
Among 24 mice there were 4 lung tumors (controls 1/29) and 4 liver tumours (controls 1/29).
No further details of the distribution of the tumours and the hispathological findings were available.
Applicant's summary and conclusion
- Conclusions:
- Benzene sulphonic acid hydrazide may have marginal tumorigenic activity in mice, but is not a strong carcinogen.
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