Registration Dossier
Registration Dossier
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EC number: 201-255-2 | CAS number: 80-17-1
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Data source
Reference
- Reference Type:
- other: QSAR-tool
- Title:
- Estimation Program Interface EPI Suite (TM) v4.11: ECOSAR v1.11
- Author:
- United States Environmental Protection Agency, Washington, DC, USA.
- Bibliographic source:
- http://www.epa.gov/oppt/exposure/pubs/episuitedl.htm
Materials and methods
- Principles of method if other than guideline:
- ECOSAR™ Version 1.11 (Sept 2012): The Ecological Structure Activity Relationships (ECOSAR) Class Program estimates the aquatic toxicity of industrial chemicals. The program estimates acute (short-term) toxicity and chronic (long-term or delayed) toxicity to aquatic organisms to fish, aquatic invertebrates and green algae.
- GLP compliance:
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3 776.089 mg/L
- Basis for effect:
- mortality
Any other information on results incl. tables
ECOSAR Program (v1.11) Results:
===============================
ECOSAR Version 1.11 Results Page
SMILES : c1ccc(cc1)S(=O)(=O)NN
CHEM : Benzenesulphonohydrazide
CAS Num:
ChemID1:
MOL FOR: C6 H8 N2 O2 S1
MOL WT : 172.20
Log Kow: 0.007 (EPISuite Kowwin v1.68 Estimate)
Log Kow: (User Entered)
Log Kow: -0.14 (PhysProp DB exp value - for comparison only)
Melt Pt: 102.00 (deg C, User Entered for Wat Sol estimate)
Melt Pt: 102.00 (deg C, PhysProp DB exp value for Wat Sol est)
Wat Sol: 6.521E+004 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: 1.5E+004 (mg/L, User Entered)
Wat Sol: (PhysProp DB exp value)
--------------------------------------
Values used to Generate ECOSAR Profile
--------------------------------------
Log Kow: 0.007 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 1.5E+004 (mg/L, User Entered)
--------------------------------------
ECOSAR v1.11 Class-specific Estimations
--------------------------------------
Amides
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Amides : Fish 96-hr LC50 1369.188
Amides : Daphnid 48-hr LC50 3776.089
Amides : Green Algae 96-hr EC50 28.011
Amides : Fish ChV 0.718
Amides : Daphnid ChV 56.830
Amides : Green Algae ChV 11.351
Amides : Fish (SW) 96-hr LC50 1185.207
Amides : Mysid (SW) 96-hr LC50 39.973
=========================== ================== ======== ====== ==========
Neutral Organic SAR : Fish 96-hr LC50 8718.941
(Baseline Toxicity) : Daphnid 48-hr LC50 4118.588
: Green Algae 96-hr EC50 1433.592
: Fish ChV 685.961
: Daphnid ChV 240.680
: Green Algae ChV 249.207
Note: * = asterisk designates: Chemical may not be soluble enough to
measure this predicted effect. If the effect level exceeds the
water solubility by 10X, typically no effects at saturation (NES)
are reported.
------------------------------
Class Specific LogKow Cut-Offs
------------------------------
If the log Kow of the chemical is greater than the endpoint specific cut-offs
presented below, then no effects at saturation are expected for those endpoints.
Amides :
-------
Maximum LogKow: >8.5 (LC50)
Maximum LogKow: >8.0 (EC50,ChV)
Baseline Toxicity SAR Limitations:
---------------------------------
Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)
Maximum LogKow: 6.4 (Green Algae EC50)
Maximum LogKow: 8.0 (ChV)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
