Registration Dossier
Registration Dossier
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EC number: 907-284-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Regarding the consensus of different QSAR Database (Danish QSAR Database, OECD QSAR Toolbox v4.3, Nexus DEREK), the Mixture of Methyl Linolenate, Methyl linoleate and Methyl oleate is predicted as non-irritant to the skin.
According to OECD QSAR Toolbox v4.2 and Nexus DEREK, the mixture of Methyl Linolenate, Methyl linoleate and Methyl oleate is predicted as a non-irritant to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion, other
- Remarks:
- QSAR predicted value
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6 (QSPR model adapted specifically from OECD test guideline 404)
- Principles of method if other than guideline:
- The purpose of the in silico study was to predict the Acute Skin Irritation/Corrosion of the test item - multiconstituent containing Methyl Linolenate, Methyl linoleate and Methyl oleate This prediction was performed using the following QSAR models:
* Danish QSAR Database
* OECD QSAR Toolbox v4.3 (profiling results)
* Nexus DEREK v6.0.1
The final consensus result for acute skin irritation/corrosion was derived by applying a consensus method on the reliable results derived for individual models. - Specific details on test material used for the study:
- SMILES:
* Methyl Linolenate: O=C(OC)CCCCCCCC=CCC=CCC=CCC
* Methyl Linoleate: O=C(OC)CCCCCCCC=CCC=CCCCCC
* Methyl oleate: O=C(OC)CCCCCCCC=CCCCCCCCC - Remarks on result:
- other: non-irritant to the skin
- Remarks:
- QSAR predicted value
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Regarding the consensus of different QSAR Database (Danish QSAR Database, OECD QSAR Toolbox v4.3, Nexus DEREK), the Mixture of Methyl Linolenate, Methyl linoleate and Methyl oleate is predicted as non-irritant to the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6 (QSPR model adapted specifically from OECD test guideline 405)
- Principles of method if other than guideline:
- The purpose of the in silico study was to predict the Acute Eye Irritation/Corrosion potential of the test item - multiconstituent containing Methyl Linolenate, Methyl Linoleate and Methyl Oleate. This prediction was performed using the following QSAR models:
* Nexus DEREK v6.0.1
* OECD QSAR Toolbox v4.3 (profiling results)
The final consensus result for Acute Eye Irritation/Corrosion was derived by applying a consensus method on the reliable results derived for individual models. - Specific details on test material used for the study:
- SMILES:
* Methyl Linolenate: O=C(OC)CCCCCCCC=CCC=CCC=CCC
* Methyl Linoleate: O=C(OC)CCCCCCCC=CCC=CCCCCC
* Methyl oleate: O=C(OC)CCCCCCCC=CCCCCCCCC - Species:
- other: Not specified
- Strain:
- not specified
- Remarks on result:
- other: Non-irritant to the eye
- Remarks:
- QSAR predicted value
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to OECD QSAR Toolbox v4.2 and Nexus DEREK, the mixture of Methyl Linolenate, Methyl linoleate and Methyl oleate is predicted as a non-irritant to the eye.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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