Registration Dossier
Registration Dossier
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EC number: 616-017-7 | CAS number: 7377-08-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Remarks:
- Intravenous
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline is specified in the report.
- GLP compliance:
- no
- Limit test:
- yes
Test material
- Reference substance name:
- 3-[(4-aminobenzoyl)amino]propanoic acid
- EC Number:
- 616-017-7
- Cas Number:
- 7377-08-4
- Molecular formula:
- C10 H12 N2 O3
- IUPAC Name:
- 3-[(4-aminobenzoyl)amino]propanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD) BR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- other: 1 N HCl (pH was adjusted to 4)
- Details on exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
- Doses:
- 150 mg/kg bw
- No. of animals per sex per dose:
- 3 animals per sex per dose
- Control animals:
- not specified
- Details on study design:
- All animals were observed for clinical signs and mortality for 48 hours. At the end of the observation period, all animals were sacrificed and subjected to complete necropsy.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 150 mg/kg bw
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality was observed during the test.
- Clinical signs:
- No clinical signs were observed during the test.
Applicant's summary and conclusion
- Conclusions:
- The acute intravenous non-lethal dose in rats was greater than 150 mg/kg.
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