Registration Dossier
Registration Dossier
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EC number: 269-130-5 | CAS number: 68187-85-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the glycol esters category will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.
For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.
Key value for chemical safety assessment
Additional information
The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the glycol esters category will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.
For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.
There is no study available, in which the short-term toxicity of fatty acids, tall-oil, esters with ethylene glycol (CAS 68187-85-9) towards fish was investigated. Therefore, read-across to the structurally related source substance ethane-1,2-diyl dioctadecanoate (CAS 627 -83 -8) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substance is characterized by similar fatty acid chain length as well as alcohol components and is therefore considered a suitable representative for the assessment of the short-term toxicity of the target substance to fish.
One experimental study investigating the short-term toxicity of the read across substance ethane-1,2-diyl dioctadecanoate (CAS 627-83-8) to freshwater fish is available (1996). The limit test was performed according to the OECD Guideline 203, under GLP conditions with the rainbow trout (Oncorhynchus mykiss). A semi-static test design was chosen. No mortalities, behavioral abnormalities ore other effects were observed after 96 h of exposure resulting in an LC50 (96 h) of > 0.3 mg/L (nominal). 0.3 mg/L was the highest concentration, which was soluble in the vehicle tetrahydrofuran (0.1 ml/L concentrated) without precipitation. No mortality was observed in the control or solvent control.
Based on the structural and chemical similarity of the target and source substance, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that fatty acids, tall-oil, esters with ethylene glycol (CAS 68187-85-9) will not cause short-term effects to fish up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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