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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018.10.31 - 2018.12.05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
23 March 2006
Deviations:
no
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
dynamic method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
24.7 Pa
Remarks on result:
other: extapolated
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
36.7 Pa
Remarks on result:
other: extapolated
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
222.5 Pa
Remarks on result:
other: extapolated

Test results of vapour pressure

The vapour pressure was measured in the temperature range from 96 °C to 102 °C. The lowest pressure (1 200 Pa) was set and the boiling section of the apparatus was heated by an electrical cartridge. To confirm its reproducibility and reliability, measured points were repeated at decreasing pressures. The measured temperatures are listed in table below.

Measurement results of vapour pressure at various temperatures.

Temperature 

Vapour

pressure

Condition
K Pa mmHg
96 369 3 200 measured up
107 380 5 600 measured up
109 382 6 133 measured up
115 388 7 999 measured up
111 384 6 799 measured down
105 378 5 66 measured down
102 375 4 400 measured down

Based on experimentally measured data, log P was expressed as a function of 1/T. From the measured data points of the vapour pressure curve, the constants A and B of the Antoine equation were calculated.

Antoine equation: Log P= A+ B*1/(T)

P : Vapour pressure in Pa

T : Temperature in K

A= 11.673

B= -3 012.2

The vapour pressure of 2,3-butanediol ((2R,3S)-rich) was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 ℃, 25 ℃ and 50 ℃.

Reaction or decomposition of the test material was not observed during the test.

Conclusions:
The vapour pressure of 2,3-butanediol ((2R,3S)-rich) was 24.7 Pa at 20 °C (293 K), 36.7 Pa at 25 °C (298 K) and 222.5 Pa at 50 °C (323 K) (extrapolated values).
Executive summary:

The vapour pressure was measured in the temperature range from 96 °C to 102 °C. The lowest pressure (1 200 Pa) was set and the boiling section of the apparatus was heated by an electrical cartridge. To confirm its reproducibility and reliability, measured points were repeated at decreasing pressures. Based on experimentally measured data, log P was expressed as a function of 1/T. From the measured data points of the vapour pressure curve, the constants A and B of the Antoine equation were calculated. The vapour pressure of 2,3-butanediol ((2R,3S)-rich) was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 ℃, 25 ℃ and 50 ℃.

The vapour pressure of 2,3-butanediol ((2R,3S)-rich) was 24.7 Pa at 20 °C (293 K), 36.7 Pa at 25 °C (298 K) and 222.5 Pa at 50 °C (323 K) [calculated by the extrapolation of the measured vapour pressure curve]. Reaction or decomposition of the test material was not observed during the test.

Description of key information

The vapour pressure of 2,3-butanediol ((2R,3S)-rich) was 24.7 Pa at 20 °C (293 K), 36.7 Pa at 25 °C (298 K) and 222.5 Pa at 50 °C (323 K) (extrapolated values).

Key value for chemical safety assessment

Vapour pressure:
36.7 Pa
at the temperature of:
25 °C

Additional information