Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 483-990-0 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Remarks:
- APP category
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Category is coherent for more than 10 endpoints. If skin irritation occured it would be related to the properties of surfactant and 2 substances in the category do not exhibit any skin irritation effect
- Justification for type of information:
- Discussed in the document attached
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Version / remarks:
- Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and
grouping of chemicals - May 2008
- Principles of method if other than guideline:
- Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and
grouping of chemicals - May 2008 - GLP compliance:
- no
Test material
- Reference substance name:
- D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)
- Molecular formula:
- C15H30O5
- IUPAC Name:
- D-xylofuranose oligomeric dodecyl glycosides (degree of polymerisation = 1)
- Reference substance name:
- D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H38O9
- IUPAC Name:
- D-xylofuranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Reference substance name:
- D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)
- Molecular formula:
- C17H34O5
- IUPAC Name:
- D-xylofuranose oligomeric tetradecyl glycosides (degree of polymerisation = 1)
- Reference substance name:
- D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H38O9
- IUPAC Name:
- D-xylofuranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Reference substance name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1
- Molecular formula:
- C15H30O5
- IUPAC Name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 1
- Reference substance name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H39O9
- IUPAC Name:
- D-glucopyranose oligomeric dodecyl glycosides, degree of polymerisation 2
- Reference substance name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1
- Molecular formula:
- C15H30O5
- IUPAC Name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 1
- Reference substance name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Molecular formula:
- C20H38O9
- IUPAC Name:
- D-glucopyranose oligomeric tetradecyl glycosides, degree of polymerisation 2
- Reference substance name:
- Glucose
- EC Number:
- 200-075-1
- EC Name:
- Glucose
- Cas Number:
- 50-99-7
- Molecular formula:
- C6H12O6
- IUPAC Name:
- D-glucose
- Reference substance name:
- Xylose
- EC Number:
- 200-400-7
- EC Name:
- Xylose
- Cas Number:
- 58-86-6
- Molecular formula:
- C5H10O5
- IUPAC Name:
- Oxane-2,3,4,5-tetrol (D)
- Reference substance name:
- Tetradecanol
- EC Number:
- 204-000-3
- EC Name:
- Tetradecanol
- Cas Number:
- 112-72-1
- Molecular formula:
- C14H30O
- IUPAC Name:
- Tetradecan-1-ol
- Reference substance name:
- Dodecan-1-ol
- EC Number:
- 203-982-0
- EC Name:
- Dodecan-1-ol
- Cas Number:
- 112-53-8
- Molecular formula:
- C12H26O
- IUPAC Name:
- Dodecan-1-ol
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Constituent 5
Constituent 6
Constituent 7
Constituent 8
Constituent 9
Constituent 10
Constituent 11
Constituent 12
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- other: Not relevant, as no effect
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- not irritating
- Conclusions:
- According to OECD-404 (reliability) absolutely no effect occurs when APP-6505 or APP-6781 are applie
d on a damaged rabbit skin. Within a category approach (see APP category report) it can be concluded
with good confidence that APP-6726 is also not a skin irritant
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
