CASOIL

Eye irritation

Administrative data

Endpoint:

eye irritation: in vitro / ex vivo

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as skin irritation and the available information indicates that it should be classified as eye irritation (Category 2)

Justification for type of information:

The valid Danish QSAR database, Battery model that integrates results from all models of CASE Ultra, Lead Scope, SciQSAR, Experimental is applied using actual analytical information of the intermediate substance, attached in the analytical information section that includes GC-MS (and headspace) data as well as C>4 hydrocarbons from EPI Suite. Due to complex combination of hydrocarbons as UVCB intermediate substance, the input data for Danish QSAR software was actual substance constituents using GC-MS (and headspace) as well as EPI suite available data for C>4 hydrocarbons to provide a comprehensive and reliable assesment that cover complete range of known and probable hydrocarbons. With the battery approach that used here, it is possible to reduce noise from individual model estimates and thereby improve accurace and/or broaden the applicability domain. In addition, available CLP data of all consituents from ECHA database is also used in combination with DTU QSAR for classification according to CLP regulation criteria. No skin corrosive constituents were identified using both methods and only 7,7% of the constituents identified as Skin irritant category 2. However, in order to be more conservative, some of the constituents that in the GCMS report did not have CAS number but reported as isomers of a known hydrocarbon are also analyzed. For those isomers, all different shapes are checked and in order to be more conservative, the isomers with eye effect are considered for the analysis.Therefore, it can be concluded that the intermediate substance implies category 2 skin irritation since it adds around 10% of the total concentration according to CLP regulation for mixtures. Moreover, almost all constituents with skin irritation category 2 effect are also considered in CLP regulation as eye irritant 2. Therefore, the substance can be considered as eye irritant category 2.