Registration Dossier
Registration Dossier
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EC number: 606-190-7 | CAS number: 18978-78-4
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12.04-14.05.2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- April 2004
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylquinolin-8-amine
- EC Number:
- 606-190-7
- Cas Number:
- 18978-78-4
- Molecular formula:
- C10H10N2
- IUPAC Name:
- 2-methylquinolin-8-amine
- Test material form:
- solid
- Details on test material:
- slightly translucent brownish crystals
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 20-22 °C
- pH:
- 7.6 ± 0.2
- Dissolved oxygen:
- 8.0 - 8.6 mg/l
- Salinity:
- 25 ml 0,08 M CaCl2 solution
+ 25 ml 0,02 M MgSO4 solution
+ 25 ml 0,03 M NaHCO3 solution
+ 25 ml 0,003 M KCl solution
in 1 L H2O (deionized) - Conductivity:
- 606 µS/cm
- Nominal and measured concentrations:
- nominal concentrations of test substance:
1.72 mg/l,
3.44 mg/l,
6.88 mg/l,
13.75 mg/l,
27.5 mg/l,
55.0 mg/l
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 17.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test), a 48 h EC50 = 17.3 mg/l was determined for 8-Aminoquinaldine.
- Executive summary:
The acute toxicity of 8-Aminoquinaldine to Daphnia magna was investigated in a study according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) under static conditions. The endpoint examined was immobilization. The daphnids were exposed to nominal concentrations of 1,72, 3,44, 6,88, 13,75, 27,5 and 55,0 mg 8 -Aminoquinaldine per litre.
The (48 h) EC50-value was determined to be 17,3 mg/L based on nominal concentrations.
The testing/validity criteria laid down in the OECD guideline 202 are fulfilled. This study is regarded as reliable without restriction.
Thus, a 48 h EC50 = 17,3 mg/L (based on nominal concentrations) has to be taken into account for the assessment.
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