N-[3-(dimethylamino)propyl] C6-9 alkyl amides

Repeated dose toxicity: dermal

Administrative data

Endpoint:

sub-chronic toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

N-[3-(dimethylamino)propyl] C6-9 alkyl amides was mildly irritating to skin but severely irritating to eyes, so any local effects would be limited to irritation. The ECHA Guidance document allows the calculation of dermal long term DNELs based on the oral NOAEL. This is conservative approach as dermal absorption can be expected to be less than by the oral route. No testing is justified which avoid unnecessary use of additional animals.