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EC number: 948-134-7
CAS number: -
A study was conducted to determine the
skin irritation potential of the test substance in male Himalayan
rabbits according to OECD Guideline 404 and EU Method B.4, in compliance
with GLP. Five-tenths of a milliliter of the test substance was applied
to the skin of three healthy rabbits for 4 h. Following exposure, dermal
irritation was evaluated by the method of Draize et al. One hour after
patch removal, all three treated sites exhibited very slight to
well-defined erythema and very slight edema. Desquamation was noted at
two or three dose sites between 72 h and Day 14. Although the overall
incidence and severity of irritation decreased gradually with time,
dermal irritation (erythema and/or desquamation) persisted for 2 animals
through Day 14 (study termination). Under the study conditions, the test
substance was moderately irritating to skin (Oley, 2009).
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