Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 948-134-7
CAS number: -
A study was conducted to determine the
potential acute toxicity of the test substance by the dermal route
according to OECD Guideline 402, EU Method B.3 and EPA OPPTS Method
870.1200, in compliance with GLP. the test susbtance was applied a
single time at 5000 mg/ kg bw to the skin of 10 healthy rats for 24 h.
The animals were observed for mortality, signs of gross toxicity and
behavioral changes at least once daily for 14 d. Body weights were
recorded prior to application and again on Days 7 and 14 (termination).
Necropsies were performed on all animals at terminal sacrifice. All
animals survived exposure to the test substance and gained body weight
during the study. Following application, all animals exhibited facial
staining and/or ano-genital staining between Days 1 and 2. Also, dermal
irritation (erythema, edema, desquamation, hyperkeratosis,
discoloration, eschar and/or corrosion) was noted at the dose site of
all animals between Days 1 and 14. Gross necropsy of the females
revealed red intestines. No gross abnormalities were noted for any of
the males when necropsied at the conclusion of the 14 d observation
period. Under the study conditions, the acute dermal LD50 of the test
substance was greater than 5000 mg/kg bw in male and female rats (Oley,
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again