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EC number: 948-134-7
CAS number: -
study was conducted to determine the hydrolysis of the test substance
according to EPA OPPTS Method 835.2120, in compliance with GLP. Under
the study conditions, 1% hydrolysis occurred at pH 7 and no hydrolys was
noted at pH 4 or pH 9 after 5 days at 49°C (Probst, 2010).
study was conducted to determine the rate and route of hydrolysis of
[14C] radiolabeled test substance in sterile pH 4, pH 7 and pH 9 buffer
according to OECD Guideline 111 and EPA OPPTS Method 835.2120, in
compliance with GLP. The substance was applied to pH 4 (0.01 M acetate),
pH 7 (0.01 M phosphate) and pH 9 (0.01 M borate) sterile aqueous buffer
solutions at concentrations of 0.969 μg/mL (0.969 ppm), 0.982 μg/mL
(0.982 ppm) and 0.955 μg/mL (0.955 ppm), respectively. The samples were
incubated for 5 days at 50 ± 0.5ºC in the dark. At selected intervals,
duplicate samples were analyzed by liquid scintillation counting (LSC)
to determine the concentration of radioactivity in solution. Samples
were then analyzed directly by high performance liquid chromatography
with radiochemical flow detection (HPLC/RAD) to determine the
distribution of radioactive residues. The material balance of
radioactivity for the sterile pH 4, pH 7 and pH 9 buffer hydrolysis
samples throughout the study ranged from 97.4-102.9 percent of the
applied radioactivity (%AR). Under the study conditions, no significant
degradation was observed in the preliminary study after 5 days at pH 4,
pH 7 and pH 9 at 50°C. Therefore, no additional experiments were
required. On the basis of the results from studies conducted at 50°C, it
can be concluded that aqueous abiotic hydrolysis will not be a
significant route of elimination of the test substance from the
environment (Grommes, 2010).
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