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EC number: 701-301-6
CAS number: -
Before the beginning of the experiment, the electrical resistance of two
skin discs was measured for each animal skin (animals no. 1 and 2). In
each case, the skin discs gave the resistance values greater than 10 kΩ;
therefore, the remainder of the skin discs of the animals could have
been used in the experiment.
Results of the control transcutaneous electrical resistance test (TER):
Skin disc number
TER value (kQ)
Experiment: results of the transcutaneous electrical resistance test
Mean TER value土SD (kO)
Positive control - 10M HCl
0.92 ± 0.01
Negative control - distilled water
The skin corrosion potential of the test substance was determined in
accordance with the OECD nº 430 with GLP. A transcutaneous electrical
resistance test (TER) was performed on skin discs of Wistar female rats
in order to obtain information on health hazards resulting from skin
contact with the test item. At the beginning of the experiment, the
animals were 21 days old. In order to control the procedure quality, the
electrical resistance of two skin discs obtained from each test animal
was measured before the start of the experiment. In each case, the skin
disc resistance values were greater than 10 kΩ; therefore, the remainder
of the animals’ skin discs could have been used in the experiment. The
undiluted test item was uniformly applied to the epidermal surface of
the skin disc placed inside a tube. Concurrent positive (10M
hydrochloric acid) and negative (distilled water) controls were used.
Three skin discs obtained from each animal were used for the test item
and three for each control item. The test item and the control items
were evenly applied to the discs for 24 hours and kept at 21-22°C. Then,
they were removed by washing with a jet of tap water. LCR 6401
low-voltage, alternating current databridge was used to measure the
electrical resistance of the skin in kΩby placing the databridge
electrodes on either side of the skin disc. After the transcutaneous
electrical resistance test (TER), the skin discs were subjected to a
gross examination in order to reveal possible damage. The dye binding
procedure was not necessary in this case since all TER values for the
test item were higher than 5 kΩand there were not any visible changes on
the skin discs. The mean TER results for the skin discs treated with the
test item were equal to 19.57 kΩ (animal no. 1) and 17.78 kΩ (animal no.
2). They can be accepted because the concurrent positive and negative
control values fell within the acceptable ranges for the method. Gross
examinations of the skin discs treated with the test item did not reveal
any pathological changes. On the grounds of the study, it may be stated
that the test substance does not lead skin corrosion/severe irritation.
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