Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 284-557-7 | CAS number: 84929-79-3 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Styrax benzoin, Styracaceae.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Result published in peer-reviewed journal, only results available with limited details on method and no guideline details.
Data source
Reference
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients
- Author:
- Bickers D et al
- Year:
- 2 005
- Bibliographic source:
- Food and Chemical Toxicology 43: 799–836
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- In an eye irritation study, the test substance was instilled at 0.1–1% in distilled water into one eye of rabbits and observations were made for up to 24 h.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- trans-cinnamic acid
- EC Number:
- 205-398-1
- EC Name:
- trans-cinnamic acid
- Cas Number:
- 140-10-3
- Molecular formula:
- C9H8O2
- IUPAC Name:
- (2E)-3-phenylprop-2-enoic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- water
- Amount / concentration applied:
- 0.1-1%
- Observation period (in vivo):
- 24 h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: eye irritation observed up to 24 h
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: eye irritation observed up to 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks on result:
- other: eye irritation observed up to 24 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: eye irritation observed up to 24 h
Applicant's summary and conclusion
- Conclusions:
- Based on study conditions, the test substance was not irritating to rabbit eye.
- Executive summary:
An eye irritation study was performed in rabbits. The test substance was instilled at 0.1–1 % in distilled water into one eye of rabbits and the observations were made up to 24 h. Based on study conditions, the test substance was not irritating to rabbit eye (Bickers, 2005).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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