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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Result published in peer-reviewed journal, only results available with no method, guideline etc.

Data source

Reference
Reference Type:
publication
Title:
A toxicologic and dermatologic assessment of related esters and alcohols of cinnamic acid and cinnamyl alcohol when used as fragrance ingredients
Author:
Belsito D
Year:
2007
Bibliographic source:
Food and Chemical Toxicology 45: S1–S23

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A maximisation pre-test was performed in human volunteers under 48 h closed patch.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamyl cinnamate
EC Number:
204-566-1
EC Name:
Cinnamyl cinnamate
Cas Number:
122-69-0
Molecular formula:
C18H16O2
IUPAC Name:
3-phenylprop-2-enyl 3-phenylprop-2-enoate

Test animals

Species:
other: human volunteer

Test system

Type of coverage:
occlusive
Vehicle:
other: petrolatum
Amount / concentration applied:
4% w/w
Duration of treatment / exposure:
48 h
Number of animals:
5 male and 5 female volunteers
Details on study design:
Human maximisation pre-test

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Reversibility:
not specified
Remarks on result:
other: individual scores not mentioned
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Reversibility:
not specified
Remarks on result:
other: individual scores not mentioned

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The constituent was not irritating to human skin (Belsito, 2007).
Executive summary:

A maximisation pre-test was conducted in human volunteers to determine the skin irritation potential of the constituent. Based on the limited results published, the constituent was not irritating to human skin (Belsito, 2007).