Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
other: Secondary source
Title:
Unnamed
Year:
1986

Materials and methods

Test guideline
Guideline:
other: not specified
Principles of method if other than guideline:
Not specified.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
Unknown purity; test material used in published study; no information on grade or analytical data included.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: inhalation. no data available whether exposure was via gas, aerosol or vapor.
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
2270 ppm; no data available whether other concentrations were tested as well.
No. of animals per sex per dose:
no data
Control animals:
not specified
Statistics:
no data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LCLo
Effect level:
2 270 ppm
Based on:
not specified
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value.
Mortality:
yes, but no details available
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Any other information on results incl. tables

No data available.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
In a RTECS data entry (reliability score 4) for Silane, chloromethylmethyldiethoxy- a LCLo of 2270 ppm/4h was recorded. No further details are available.
Executive summary:

In a RTECS data entry (reliability score 4) for Silane, chloromethylmethyldiethoxy- a LCLo of 2270 ppm/4h was recorded. No further details are available.