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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-02-01
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Purity: > 99%
Batch No.: 102Z4
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.97
Remarks on result:
other: temperature and pH unknown
Key result
Type:
Pow
Partition coefficient:
933
Remarks on result:
other: temperature and pH unknown
Details on results:
The retention time of test item was determined parallel twice, and the two values were 6.280 min and 6.290 min respectively. The lgk of test item was brought into regression equation Y=0.3626x-0.5771 (R=0.9959), the values of lgPow of test item were 2.97 and 2.97 respectively, the absolute difference of the two lgPow values was 0.00 1g units and the average of lgPow of test item was 2.97, the Pow value was 933.
Conclusions:
The Pow of test item was 933, lgPow was 2.97.
Executive summary:

The Partition Coefficient (n-octanol/water) of the test substance was determined compatible with the Principles of OECD Guidelines 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method.

Based on the test results, the Pow of the test substance was 933, lgPow was 2.97.

Description of key information

The Pow of test item was 933, lgPow was 2.97.

Key value for chemical safety assessment

Log Kow (Log Pow):
2.97

Additional information

The Partition Coefficient (n-octanol/water) of the test substance was determined compatible with the Principles of OECD Guidelines 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method.

Based on the test results, the Pow of the test substance was 933, lgPow was 2.97.