Zirconium hydroxysulphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Zirconium lactate and barium zirconate: Acute toxicity and inhalation effects in experimental animals.

Author:

Brown, JR; Mastromatteo, E; Horwood, J.

Year:

1963

Bibliographic source:

Am Ind Hyg Assoc J 24(2):131−136.

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Acute oral toxicity tests were carried out on 4 groups of six male Wistar rats. Test material was administered as a suspension in corm oil by stomach tube. The LD50 doses were calculated from the tables published by Weil.

GLP compliance:

no

Remarks:

Study pre-dates the introduction of GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Zirconium lactate

Cas Number:

60676-90-6

Molecular formula:

C12H20O12Zr

IUPAC Name:

Zirconium lactate

Specific details on test material used for the study:

Zirconium lactate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

Oral doses of 0.75, 1.5, 3.0 and 6.0 g/kg of body weight were given as range-finding doses.
Groups of six rats were then given graduated doses of 1.25, 2.5, 5.0 and 10.0 g/kg of zirconium lactate.

No. of animals per sex per dose:

6 male rats per dose.

Control animals:

not specified

Statistics:

The LD50 doses were calculated from the tables published by Weil

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In a study in male Wistar rats, the oral LD50 was found to be > 10 000 mg/kg bw, the maximum dose tested.

Executive summary:

Groups of male Wistar rats were administered zirconium lactate suspended in corn oil at doses of 1.25, 2.5, 5.0 and 10.0 g/kg. The oral LD50 was found to be greater than the maximum dose tested, i.e. > 10 g/kg bw.